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DEVELOPMENT OF DATABASE DEPICTING THE ASSOCIATION BETWEEN HLA ALLELES AND HEPATITIS B VIRAL ANTIGEN



Immunization is the organization of antigenic material (an antibody) to empower a person's immune system thereby creating a versatile resistance to a pathogen. The bioagent of a vaccine might be intact, however, inactivated or weakened (with diminished infectivity) types of the causal pathogens, or cleansed parts of the pathogen that have been observed to be exceptionally immunogenic (e.g., coat proteins of an antigen).


The intensity of Hepatitis B infection (viral persistence or clearance) depends on the strength of the host immune system. Since the antigenic peptides bind with Human Leukocyte Antigen (HLA), the polymorphic HLA genes are the key elements in the clearance of the virus. The HLA alleles mentioned here have been shown to be responsible for viral clearance in many research articles. This meta-analysis assesses the association of HLA class 1 and class 2 alleles with the specific antigenic peptides which lead to viral clearance and also signifies the importance of vaccine specificity as differences in HLA alleles may cause HBV persistence or clearance. Since it is the function of these HLA alleles to present the antigenic peptides to the T cells, antigen specificity is of most importance and their best binding with the specific HLA alleles responsible for viral clearance should be the only aim of vaccination.


So here, the necessity of antigen specificity with HLA molecules in vaccination will be highlighted in order to avoid autoimmune disorders in the future and this database will help other researchers to categorize vaccinations according to the HLA alleles found in the body.



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